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Glycerophosphoryl diester phosphodiesterase. , Yutani, K.
- Glycerophosphoryl diester phosphodiesterase. Here, we characterized the Arabidopsis GDPD family that can be SHV3 encodes a novel protein with two tandemly repeated glycerophosphoryl diester phosphodiesterase-like domains and a glycosylphosphatidylinositol anchor, and several of its paralogs are found in Arabidopsis. . -. Loss of two pollen-specific GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE-LIKE (GDPD-LIKE) protein Sep 8, 2011 · Two genes encoded putative enzymes involved in phospholipid metabolism, GdpD (which denotes glycerophosphoryl diester phosphodiesterase) and Cls (which denotes cardiolipin synthetase), and one gene encoded a putative membrane protein, LiaF (which denotes lipid II cycle-interfering antibiotics protein but whose exact function is not known). Characteristics of a ugp-encoded and phoB-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the ugp transport system of Escherichia coli. 30. Mar 18, 2004 · Crystal Structure of Glycerophosphoryl Diester Phosphodiesterase complexed with Glycerol Ishijima, J. J. Bacterial glycerophosphodiester phosphodiesterases (GP-PDEs), GlpQ and UgpQ, are well-characterized periplasmic and cytosolic proteins that play UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information. Aug 20, 2008 · The Glycerophosphoryl Diester Phosphodiesterase-Like Proteins SHV3 and its Homologs Play Important Roles in Cell Wall Organization Get access Shimpei Hayashi, Dec 24, 2013 · The glycerophosphodiester phosphodiesterases are evolutionarily conserved proteins that have been linked to several patho/physiological functions, comprising bacterial pathogenicity and mammalian cel The Glycerophosphoryl Diester Phosphodiesterase-Like Proteins SHV3 and its Homologs Play Important Roles in Cell Wall Organization Shimpei Hayashi 1,2, Tadashi Ishii 3, Toshiro Matsunaga 4, Rumi Jul 17, 2025 · UniProtKB/Swiss-Prot: GDPD3_HUMAN : Belongs to the glycerophosphoryl diester phosphodiesterase family. , 1989 M. Oct 11, 2018 · OsGDPD2 overexpression enhances Pi content of rice seedlings via lipid remodeling and improved root architecture. Glycerophosphodiester phosphodiesterase (GDPD), which hydrolyzes glycerophosphodiesters into sn-glycerol-3-phosphate (G-3-P) and the corresponding alcohols, plays an important role in various physiological processes in both prokaryotes and eukaryotes. Streptomyces antibioticus phosphatidylinositol-specific phospholipase Aug 23, 2007 · Abstract. Glycerophosphoryl diester phosphodiesterase (GDPD) enzymes are involved in phosphate homeostasis and phospholipid catabolism for energy production. These proteins are crucial for the pathogenicity of bacteria and for bioremediation processes aime … Brzoska P. Gene: gpdq. 2854 Crossref View in Scopus Google Scholar Kelley et al. All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3. The glpQ gene encodes a periplasmic enzyme of 333 amino acids, produced initially with a 25 residue long signal sequence, while ugpQ codes for a c … SHAVEN3 (SHV3) is a glycerophosphoryl diester phosphodiesterase-like protein, involved in cell wall organization and root hair morphogenesis [15, 68]. 46) catalyzes the hydrolysis of a glycerophosphodiester to an alcohol and glycerol 3-phosphate in glycerol metabolism. Pyruvate metabolism Six gene families, including pps, ppdK, pyk, pckG, ppc, and pckA, are involved in pyruvate metabolism. Dec 24, 2013 · The glycerophosphodiester phosphodiesterases are evolutionarily conserved proteins that have been linked to several patho/physiological functions, comprising bacterial pathogenicity and mammalian cel Aug 20, 2008 · The Glycerophosphoryl Diester Phosphodiesterase-Like Proteins SHV3 and its Homologs Play Important Roles in Cell Wall Organization Get access Shimpei Hayashi , Jul 13, 2014 · Phosphatidylinositol-specific phospholipases C (PI-PLC) are known to participate in many eukaryotic signal transduction pathways and act as virulence factors in lower organisms. 功能概要 预计可启用甘油磷酸胆碱磷酸二酯酶活性。预测参与甘油磷脂分解代谢过程。预测作用于骨骼肌组织发育的上游或内部。预测位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable glycerophosphocholine phosphodiesterase activity. Characterization of two genes, glpQ and ugpQ, encoding glycerophosphoryl diester phosphodiesterases of Escherichia coli. However, the function of GPX-PDEs in phosphate remobilization in maize remains unclear. Expression_system_taxid: 562. Source: Enterobacter aerogenes. You can use this browser Dec 3, 2024 · glpQ glycerophosphoryl diester phosphodiesterase GlpQ [] Gene ID: 946725, updated on 3-Dec-2024 Summary Other designations glycerophosphoryl diester phosphodiesterase GlpQ GeneRIFs: Gene References Into Functions N-terminus verified by Edman degradation on mature peptide The nucleotide sequences of the glpQ and ugpQ genes of Escherichia coli, which both encode glycerophosphoryl diester phosphodiesterases, were determined. Glycerophosphoryl diester phosphodiesterase-like protein involved in cell wall cellulose accumulation and pectin linking. Mar 1, 2025 · A novel cold-active glycerophosphodiester phosphodiesterase and its application in whole-cell catalytic degradation of diphenyl phosphate at low temperature Jul 17, 2025 · UniProtKB/Swiss-Prot: GDPD1_HUMAN : Belongs to the glycerophosphoryl diester phosphodiesterase family. Chains: A, B (271 residues) CATH domains: 3. Makino, M. & Boos, W. Mar 1, 2007 · Characteristics of a ugp-encoded and phob-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the ugp transport system of Escherichia coli The Glycerophosphoryl Diester Phosphodiesterase-Like Proteins SHV3 and its Homologs Play Important Roles in Cell Wall Organization Apr 1, 2014 · The PLD of these very different groups appear to have had a common evolutionary origin in the glycerophosphoryl diester phosphodiesterase (GDPD) protein family, due either to independent events of duplication and genetic divergence or to lateral gene transference (Binford et al. In this study we identified highly conserved amino acids of the glycerophosphoryl diester phosphodiesterase (GDPD) domain of recombinant LlPLD1, which interact with the substrate sphingomyelin. Glycerophosphodiester phosphodiesterase GlpQ [110382] Escherichia coli [TaxId: 562] [110383] (3) SQ P09394 1ydy automatically matched to d1t8qb_ complexed with ca, gol region a:29-356 [123006] 1ydy automatically matched to d1t8qb_ complexed with ca, gol region b:29-356 [123007] 1t8q Structural genomics target complexed with gol, mg chain a Consistent with this observation are the absence of a glycerophosphoryl diester phosphodiesterase activity in preparations of periplasmic proteins of a ugp+ glpT glpQ strain (data not shown) and glycerophosphoryl diester phosphodiesterase [Vibrio cholerae O1 biovar El Tor str. Jul 9, 2009 · Tommassen J, Eiglmeier K, Cole ST, Overduin P, Larson TJ, Boos W. Moreover, we identified an open reading frame that codes for 145 amino acids (ORF145), whose deduced amino acid sequence showed 57% amino acid sequence similarity to the N terminus of the glycerophosphoryl diester phosphodiesterase (UgpQ) of Escherichia coli. Here, we report the detailed characterization of mutants of SHV3 and one of its paralogs, SVL1. - Here, we show that OsGDPD2 is a Pi deficiency responsive gene, which is transcriptionally regulated by OsPHR2. Jul 17, 2025 · UniProtKB/Swiss-Prot: GDPD2_HUMAN : Belongs to the glycerophosphoryl diester phosphodiesterase family. Full expression of DAP resistance requires additional mutations in enzymes (glycerophosphoryl diester phosphodiesterase and cardiolipin synthase) that alter cell membrane phospholipid content. 4125-4135. Jul 17, 2025 · UniProtKB/Swiss-Prot: GDPD5_HUMAN : Belongs to the glycerophosphoryl diester phosphodiesterase family. 91 A The Staphylococcus aureus mec determinant comprises an unusual cluster of direct repeats and codes for a gene product similar to the Escherichia coli sn-glycerophosphoryl diester phosphodiesterase. 1128/jb. 46) is a relatively poorly characterized enzyme that catalyses the hydrolysis of various glycerophosphodiesters (glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, glycerophosphoserine and bis-glycerophosphoglycerol), releasing sn-glycerol 3-phosphate and the corresponding alcohol. , 2005, Cordes and Binford, 2006, Murakami et al. PF03009) that catalyze hydrolysis of a broad range of glycerophosphodiesters like glycerophosphocholine, glyc-erophosphoethanolamine, and glycerophosphoglycerol. Dec 18, 2018 · Background Venom-expressed sphingomyelinase D/phospholipase D (SMase D/PLD) enzymes evolved from the ubiquitous glycerophosphoryl diester phosphodiesterases (GDPD). Bacteria express a family of glycerophosphoryl diester phosphodiesterases (Pfam accession no. To be published. , 2006). Brzoska P, Boos W (1988) Characteristics of a ugp-encoded and phoB-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the ugp transport system of Escherichia coli. May 17, 2007 · Crystal structure of glycerophosphodiester phosphodiesterase (GDPD) from Thermoanaerobacter tengcongensis, a metal ion-dependent enzyme: insight into the catalytic mechanism. However, the function of GPX-PDEs in Oct 14, 2024 · FOC50_RS05990 glycerophosphoryl diester phosphodiesterase membrane domain-containing protein [] Gene ID: 84802796, updated on 14-Oct-2024 Summary Other designations glycerophosphoryl diester phosphodiesterase membrane domain-containing protein Jul 4, 2022 · The pafA gene encodes Pi-insensitive phosphomonoesterase, and ugpQ and glpQ code for cytoplasmic glycerophosphoryl diester phosphodiesterase and periplasmic glycerophosphoryl diester phosphodiesterase, respectively. The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases. Apr 4, 2023 · In flowering plants, pollen tube wall integrity is essential for double fertilization and seed formation. However, little is known about the physiological significance of GDPD in plants. Apr 11, 1989 · Megumi Kasahara, Kozo Makino, Mitsuko Amemura, Atsuo Nakata; Nucleotide sequence of the ugpQ gene encoding glycerophosphoryl diester phosphodiesterase of Escher Enzyme Nomenclature DatabaseData © 2001–2024 IUBMB Web site © 2005–2024 Andrew McDonald UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information. We report the crystal structure of the Thermoanaerobacter tengcongensis GDPD (ttGDPD) at 1. Feb 15, 2011 · Glycerophosphodiester phosphodiesterase (GDPD), which hydrolyzes glycerophosphodiesters into sn -glycerol-3-phosphate (G-3-P) and the corresponding alcohols, plays an important role in various physiological processes in both prokaryotes and eukaryotes. Expression of GDPD-like SMaseD/PLD toxins in both arachnids and bacteria has inspired consideration of the relative contributions of lateral gene transfer and convergent recruitment in the evolutionary history of this lineage 功能概要 该基因编码甘油磷酸二酯磷酸二酯酶家族的一个成员，该酶催化脱酰甘油磷脂水解为磷酸甘油和醇。编码的蛋白质定位于细胞质并集中在核周区域附近。可变剪接导致多个转录本变体。 [RefSeq 提供，2009 年 10 月] This gene encodes a member of the glycerophosphodiester phosphodiesterase family of Enzymes that catalyze In this study we identified highly conserved amino acids of the glycerophosphoryl diester phosphodiesterase (GDPD) domain of recombinant LlPLD1, which interact with the substrate sphingomyelin. Phospholipid degradation liberates phosphate to cope with phosphate deficiency. Apr 25, 2022 · Characterization of the Arabidopsis glycerophosphodiester phosphodiesterase (GDPD) family reveals a role of the plastid-localized AtGDPD1 in maintaining cellular phosphate homeostasis under phosphate starvation. 1988, 170, 4125–4135. Additional information, provided for both this family and the superfamily it belongs to, includes SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information. Predicted to be involved in glycerophospholipid catabolic process Characteristics of a ugp‐encoded and phoB‐dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the Ugp transport system of Escherichia coli Article Feb 11, 2020 · Combining survival analysis, we identified glycerophosphodiester phosphodiesterase 1 (GDE1) as the most significant gene associated with histological typing and prognosis. ; Boos, W. 60. 180 2oog Crystal structure of glycerophosphoryl diester phosphodiesterase from staphylococcus aureus Glpq glycerophosphoryl diester phosphodiesterase [ Bombyx mori (domestic silkworm) ] Gene ID: 692531, updated on 5-Sep-2025 <p>Phosphate deficiency is one of the leading causes of crop productivity loss. The hydrolysis of deacylated glycerophospholipids into sn-glycerol 3-phosphate and alcohol is facilitated by evolutionarily conserved proteins known as glycerophosphodiester phosphodiesterases (GDPDs). Jul 17, 2025 · UniProtKB/Swiss-Prot: GDPD4_HUMAN : Belongs to the glycerophosphoryl diester phosphodiesterase family. Sep 1, 2008 · SHAVEN3 (SHV3) is a glycerophosphoryl diester phosphodiesterase-like protein, involved in cell wall organization and root hair morphogenesis [15, 68]. PF03009) that catalyze hydrolysis of a broad range of glycerophosphodiesters like glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoglycerol. 9. Here, we report that glycerophosphoryl diesters (deacylated phospholipids) are also high-affinity substrates for the ugp-encoded sy … May 10, 1983 · The phosphodiesterase did not hydrolyze bis (p-nitrophenyl)phosphate, asubstrate for periplasmic cyclic phosphodiesterase of E. Dec 24, 2013 · The glycerophosphodiester phosphodiesterases are evolutionarily conserved proteins that have been linked to several patho/physiological functions, comprising bacterial pathogenicity and mammalian cell proliferation or differentiation. , 17 (1989), p. The ugp-encoded transport system of Escherichia coli accumulates sn-glycerol-3-phosphate with high affinity; it is binding protein mediated and part of the pho regulon. SHV3 encodes a novel protein with two tandemly repeated glycerophosphoryl diester phosphodiesterase-like domains and Dec 1, 2015 · The glycerophosphoryl diester phosphodiesterase (GlpQ) protein encodes a periplasmic glycerophosphoryl diester phosphodiesterase activity (GDP), which hydrolyzes deacylated phospholipids (glycerophosphoalcohol from phospholipids) to an alcohol and glycerol-3-P (G3P) that is subsequently transported into the cell by the glycerol-3-phosphate NCBIfam NF008354 PRK11143. 4. They maintain glycerol 3-phosphate concentration, which is important for phospholipid synthesis and remodeling [1]. N16961] The dru sequences are responsible for the length polymorphism of mec. Sep 8, 2011 · Two genes encoded putative enzymes involved in phospholipid metabolism, GdpD (which denotes glycerophosphoryl diester phosphodiesterase) and Cls (which denotes cardiolipin synthetase), and one Fur- tide s quence of th ugpQ gene encoding glycerophosphoryl thermore, GlpQ seems tocontain a large insertion from diester phosphodiesterase of Escherichia coli K-12. Amemura, A. 1704125-4135. Conclusion: GDE4 and GDE7 can hydrolyze 1-acyl-lyso-PC and lyso-PAF to produce 1-acyl-lysophosphatidic acid (LPA) and Oct 1, 1988 · Characteristics of a ugp‐encoded and phoB‐dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the Ugp transport system of Escherichia coli October 1988 Abstract Glycerophosphodiester phosphodiesterase (GDPD; EC 3. 21. May 30, 2016 · Brzoska, P. Bacteriol. coli (26). Broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol and bis (glycerophospho)-glycerol are hydrolyzed. 1988. Jul 23, 2013 · Full expression of DAP resistance requires additional mutations in enzymes (glycerophosphoryl diester phosphodiesterase and cardiolipin synthase) that alter cell membrane phospholipid content. , Yutani, K. This KEGG Orthology entry describes the enzyme glucose-6-phosphate isomerase, involved in glycolysis and gluconeogenesis pathways. The glpQ gene encodes a periplasmic enzyme of 333 amino acids, produced initially with a 25 residue long signal sequence, while ugpQ codes for a cytoplasmic protein of 247 amino acids. GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE, PERIPLASMICGlycerin; Propane-1,2,3-triolGlycerolMagnesium IonBiological Unit for 1T8Q: dimeric; determined by author and by software (PISA) Dec 1, 2023 · The microbiome and metabolic processes occurring in the soil of the moss crust-soil continuum contribute to drive biogeochemical cycles. , 2000 7 Brzoska P & Boos W (1988) Characteristics of a ugp-encoded and phoB-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the ugp transport system of Escherichia coli. doi: 10. Two genes encoded putative enzymes involved in phospholipid metabolism, GdpD (which denotes glycerophosphoryl diester phosphodiesterase) and Cls (which denotes cardiolipin synthetase), and one gene encoded a putative membrane protein, LiaF (which denotes lipid II cycle-interfering antibiotics protein but whose exact function is not known). Characteristics of a ugp -encoded and phoB -dependent glycerophosphoryl the nitrogen-fixing diester phosphodiesterase which is physically dependent on the ugp transport Aug 20, 2008 · SHV3 encodes a novel protein with two tandemly repeated glycerophosphoryl diester phosphodiesterase-like domains and a glycosylphosphatidylinositol anchor, and several of its paralogs are found in Arabidopsis. Impacts root hair, trichome and epidermal cell development. 1 1 hit PANTHER PTHR43620:SF7 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED 1 hit PTHR43620 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE 1 hit PROSITE View protein in PROSITE PS51704 GP_PDE 1 hit PS51257 PROKAR_LIPOPROTEIN 1 hit Pfam Characteristics of a ugp-encoded and phoB-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the ugp transport system of Escherichia coli. 750. Jun 1, 1989 · All attempts to detect the glycerophosphoryl- diester phosphodiesterase activity in cellular ex- tracts (cytoplasmic or periplasmic), membranes, or combination thereof have so far failed. Feb 1, 2021 · Glycerophosphodiester phosphodiesterases (GPX-PDEs) hydrolyse the intermediate products of phospholipid catabolism glycerophosphodiesters into glycerol-3-phosphate, a precursor of phosphate. Jul 17, 2025 · UniProtKB/Swiss-Prot: GPCP1_HUMAN : Belongs to the glycerophosphoryl diester phosphodiesterase family. Aug 5, 2008 · Results Glycerophosphoryl Diester Phosphodiesterase Homologs. , Boos W. Characteristics of a ugp-encoded and phoB-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the Ugp transport system of Escherichia coli. Mar 16, 2024 · GDPDs are highly conserved proteins of the hydrolases family that act on phosphoric diester bonds and have biological and biochemical functional diversity. Jan 23, 2008 · REFERENCES Periplasmic glycerophosphodiester phosphodiesterase of Characterization of two genes, glpQ and ugpQ, encoding glycerophosphoryl diester phosphodiesterases of Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Jun 1, 2004 · The glycerophosphoryl diester phosphodiesterase family protein is basically responsible for maintaining cellular phosphate homeostasis under phosphate starvation and organization of primary cell Bacterial glycerophosphodiester phosphodiesterases (GP-PDEs), GlpQ and UgpQ, are well-characterized periplasmic and cytosolic proteins that play critical roles in the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol, which are utilized as major sources of carbon and ph … May 19, 2017 · Brzoska, P. - All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3. 1988;170:4125–4135. The mutation of W256 to serine and D259 to glycine decreased significantly the sphingomyelinase and hemolytic activity when compared to wild type LlPLD1. Indeed, under P limitation, the four most highly expressed proteins included a predicted glycerophosphoryl diester phosphodiesterase and three putative alkaline phosphatases (Data S3). In this study… Background: The known mammalian glycerophosphodiester phosphodiesterases hydrolyze glycerophosphodiesters. Despite differences in size and cellular location Abstract GPX-PDE (glycerophosphodiester phosphodiesterase; EC 3. 170. We isolated an allele of the shaven3 (shv3) mutant of Arabidopsis thaliana, which exhibits ruptured root hair cells during tip growth. Kasahara, K. 1. Glycerophosphodiester phosphodiesterases (GPX-PDEs) hydrolyse the intermediate products of phospholipid catabolism glycerophosphodiesters into glycerol-3-phosphate, a precursor of phosphate. Our findings describe a novel mechanism of bacterial resistance to cationic antimicrobial peptides. Thus, the enzyme recognizes the glycerophospho moiety and apparently does not hydrolyze other types of phosphodiester bonds. Jan 25, 2007 · Crystal structure of glycerophosphoryl diester phosphodiesterase from Staphylococcus aureus Glycerophosphoryl Diester Phosphodiesterase Homologs. Organism_taxid: 548. 40 3. However, little is known about the physiological … Dec 1, 1991 · The dru sequences are responsible for the length polymorphism of mec. Results: New members of the glycerophosphodiester phosphodiesterase family, GDE4 and GDE7, cannot hydrolyze glycerophosphodiesters but show lysophospholipase D activity. Sep 8, 2011 · Two genes encoded putative enzymes involved in phospholipid metabolism, GdpD (which denotes glycerophosphoryl diester phosphodiesterase) and Cls (which denotes cardiolipin synthetase), and one gene encoded a putative membrane protein, LiaF (which denotes lipid II cycle-interfering antibiotics protein but whose exact function is not known). Nakata Nucleotide sequence of the ugpQ gene encoding glycerophosphoryl diester phosphodiesterase of Escherichia coli K-12 Nucleic Acids Res. Despite the importance of extracellular events in cell wall organization and biogenesis, the mechanisms and related factors are largely unknown. Expressed in: escherichia coli. It has an important role in the synthesis of a variety of products that participate in many biochemical pathways. Characterization of the Arabidopsis glycerophosphodiester phosphodiesterase (GDPD) family reveals a role of the plastid-localized AtGDPD1 in maintaining cellular phosphate homeostasis under phosphate starvation Yuxiang Cheng1,2, Wenbin Zhou1, Nabil Ibrahim El sheery1, Carlotta Peters3,4, Maoyin Li3,4, Xuemin Wang3,4 and Jirong Huang1,* The SCOP classification for the Glycerophosphoryl diester phosphodiesterase family. Jul 17, 2025 · UniProtKB/Swiss-Prot: GDE1_HUMAN : Belongs to the glycerophosphoryl diester phosphodiesterase family. In silico analysis of active site residues and enzymatic assays confirmed phosphodiesterase activity of OsGDPD2. In a previous study Glycerophosphoryl diester phosphodiesterase-like protein involved in cell wall cellulose accumulation and pectin linking. The nucleotide sequences of the glpQ and ugpQ genes of Escherichia coli, which both encode glycerophosphoryl diester phosphodiesterases, were determined. Apr 12, 2006 · View in Scopus Google Scholar Kasahara et al. 5sxw9m tqruq or1pd ifi2 dlnk sfyhn bzpmm yyud nlaui jov